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Dermatoses in Children and Neonates

de Benedictis FM, Franceschini F, Hill D et al. Allergy 2009;64:295–303.

There are variations between countries in the type of allergens to which infants with atopic eczema are sensitized. The current authors assessed the prevalence of atopy in a number of countries to determine patterns of allergic sensitization in infants in these countries.

The current investigators carried out a large, prospective study involving 2184 infants from different European countries, Australia, and South Africa, in which total and specific levels of immunoglobulin E (IgE) were measured. The children had to have atopic dermatitis with a Severity Scoring of Atopic Dermatitis index ≥10 and a positive first-degree family history of asthma, eczema, or allergic rhinitis. All tests were performed in three central laboratories according to the same protocols. A specific antibody level of ≥0.35 kUA/L was regarded as positive. A total level of IgE ≥30 kU/L confirmed the diagnosis of atopy.

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