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Nair RP, Duffin KC, Helms C et al. Nat Genet 2009;41:199–204.

Psoriasis is a recurrent, chronic, immunologically mediated disorder with a considerable genetic predisposition. Althoughremarkable progress has recently been made in identifying genes and genetic loci associated with psoriasis, identification of additional susceptibility loci is still needed. The present study reports a highly significant association between seven genetic loci and susceptibility to psoriasis.

Psoriasis has a strong familial component and different susceptibility loci have been identified, but the exact genes that cause the disease have not yet been fully identified. The purpose of the present study was to detect additional psoriasis susceptibility loci. To identify these loci, a genome-wide association scan of 1409 patients with psoriasis and 1436 controls was conducted. The approach used provided approximately 70% power to detect loci that are well tagged by genotyped single nucleotide polymorphisms (SNPs), that increase disease risk by >1.35-fold, and have a frequency of >20%. In total, 21 SNPs representing 18 independent loci were selected for further analysis – seven of these loci were shown to be strongly associated with the risk of developing psoriasis, with combined p values of <5 × 10–8.

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