Psoriatic arthritis (PsA) is an inflammatory arthritis occurring in individuals with psoriasis. It is a multifaceted condition that – in addition to skin and nail psoriasis – presents with peripheral and/or axial arthritis/synovitis, spondylitis, dactylitis, or enthesitis, as well as iritis and various degrees of bowel inflammation. Treatment of PsA targets these clinical manifestations with the goals of improving signs and symptoms of inflammation, optimization of functional capacity and quality of life, and inhibition of progression of structural damage. Introduction of targeted biological agents has made it possible to achieve such goals in a large proportion of patients affected with PsA. Herein, we review recent advances in and current evidence-based treatments of PsA.