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Introducing a New Journal: Advances in Venous Arterial Thrombosis

Stavros V Konstantinides MD, PhD, FESC

Hemostasis is a vital process that maintains the integrity of the circulatory system after injury to the wall of an artery or vein. Following the loss of the endothelial barrier and the extravasation of blood, circulating platelets adhere to the site of injury, become activated, and aggregate. Their integration into the developing thrombus depends on the concomitant activation of the coagulation cascade, which is initiated by tissue factor and results in (primarily) factor X-mediated generation of thrombin and fibrin. Thrombosis, on the other hand, is a pathological, potentially life-threatening condition characterized by failure of the homoeostatic mechanisms that serve to maintain unobstructed blood flow in intact vessels. Every day, physicians of almost all medical and surgical disciplines engage in the fight against thrombosis to prevent death and serious morbidity. When doing so, they must also constantly keep in mind that patients may bleed to death if the antithrombotic agents used go “too far”, and destroy the delicate balance between hemostasis and thrombosis.

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