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The Hedgehog Signaling Pathway in Breast Cancer

Chandra P Prasad, PhD

According to public health figures, the global burden of breast cancer in women, measured by incidence, mortality, and economic costs, is substantial and on the increase [1]. Worldwide, 1 million women are diagnosed with breast cancer every year, and more than 410000 will die from the disease, representing 14% of female cancer-related deaths [2–4]. These figures clearly underscore the need for new therapies, and a better understanding of the mechanisms that underlie the development of breast cancer would help to identify novel molecular targets for treatment.

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