Postma EL, Verkooijen HM, van Esser S et al.; the ROLL study group.
University Medical Centre Utrecht, Utrecht, The Netherlands.
Breast Cancer Res Treat 2012;136:469–78.
Murid Chaudary’s review: Owing to mammography screening and improvements in diagnostic methods, the majority of breast cancers are detected as small, non-palpable lesions that are amenable to breast-conserving surgery (BCS). Non-palpable tumors are at substantial risk of incomplete excision, as the involved area is difficult to precisely determine. Therefore, accurate tools to determine the localization of non-palpable tumors are necessary. Although wire-guided localization (WGL) is a useful localization tool, it does not give an indication of the extent of the tumor, and the surgeon has to estimate the amount of tissue to excise. WGL can result in incomplete tumor resection in up to 50% of patients (Expert Rev Anticancer Ther 2011;11:1295–302). In addition, insertion of the wire is time consuming, requires an extra mammography, and can be uncomfortable and painful for the patient.