Gabos Z, Thoms J, Ghosh S et al.
University of Alberta, Edmonton, AB, Canada.
Breast Cancer Res Treat 2010;124:187–94.
Editor’s note: Invasive breast cancer is a heterogeneous group of neoplasms with regard to molecular alterations, cellular composition, and response to treatment. Conventional clinicopathological factors such as histological grade and type, tumor size, lymph node involvement, surgical margins, and lymphovascular invasion provide prognostic information and are routinely used in decision-making regarding locoregional treatment. The aim of the present study was to determine the impact of breast cancer biological subtypes defined by hormone receptors (estrogen receptor [ER] and progesterone receptor [PR]) and HER2 on the risk of locoregional recurrence (LRR) in newly diagnosed women treated with either breast-conservation therapy (BCT) or modified radical mastectomy (MRM).