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A Review of Corticosteroid Hypersensitivity

Yvonne Mukasa and Mark Wilkinson

Hypersensitivity to corticosteroids is now increasingly recognized. Despite this, it is likely that the true prevalence remains underestimated. The diagnosis may not always be clinically apparent, and there may often be difficulty in making a diagnosis. Clinical indicators of hypersensitivity to corticosteroids may be apparent, for example, treatment failure or deterioration of the patient’s condition. Hypersensitivity reactions may occur following topical or systemic administration, and various cutaneous and non-cutaneous reaction patterns have been described. Reports indicate that non-fluorinated molecules are more likely to sensitize than fluorinated molecules.

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