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Editor’s note: This report summarizes the newly updated guidelines for the useof methotrexate in the treatment of psoriasis.These guidelines, with specific recom-mendations on dosing and monitoring, were approved by all the members of the Medical Board of the National Psoriasis Foundation. Although methotrexate was approved by the US Food and Drug Administration for the treatment of psoriasis in 1972, it is only recently that three blinded studies have confirmed the drug’s efficacy in this setting (
N Engl J Med 2003;349:658–65,
Br J Dermatol 2008;158:116–21,
Br J Dermatol 2008;158:558–66).