Abbas O, Mahalingam M.
American University of Beirut Medical Center, Beirut, Lebanon.
J Cutan Pathol 2009;36:613–9.
Editor’s note: Muir–Torre syndrome (MTS) is a rare autosomal dominant genodermatosis that is associated with sebaceous tumors (adenomas, epitheliomas, and carcinomas), keratoacanthomas, and internal malignancies (predominantly gastrointestinal and genito-urinary). It is caused by mutations in one or more DNA mismatch repair (MMR) genes, such as
MSH-2,
MLH-1, and
MSH-6. Sebaceous tumors are variably associated with MTS, with an association of 25–60% for sebaceous adenoma (
J Am Acad Dermatol 1995;33:90–104,
J Cutan Pathol 2003;30:178–84,
J Invest Dermatol 2003;120:858–64,
Mod Pathol 2008;21:159–64).