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Therapeutics

Joly P, Roujeau JC, Benichou J et al.

University of Rouen, Rouen, France.

 J Invest Dermatol 2009;129:1681–7.

Editor’s note: Bullous pemphigoid (BP) is a chronic, autoimmune, subepidermal, blistering skin disease. It mainly affects elderly patients and presents as pruritic urticated plaques and large, tense bullae. There is a high prevalence of neurological and cardiovascular disorders among affected individuals. BP is often treated with systemic corticosteroids, but high doses of such treatment have been associated with poor survival rates (Arch Dermatol 1998;134:465–9, Arch Dermatol 2002;138:903–8). Topical steroids can be useful and research has shown high doses of topical clobetasol to be even more effective than oral prednisone for controlling BP (N Engl J Med 2002;346:321–7).

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