Please note that only limited free access to this journal is available in your country or territory.

To access the full content of this article you must purchase it (US$9.49). After payment of this one-off fee, you will gain unrestricted online access to the article and a PDF version sent to your email.

As part of our special introductory offer, after purchasing this article you will have unrestricted access to all the articles in this issue for free!

Registered users can purchase/access the article by logging in below. To register for free click here

Registered users login here:

  • Email Address:
     
  • Password:
     
  •  
If you have forgotten your password click here
0 rating

Basic Science – Diabetes

Kim SJ, Nian C, Doudet DJ et al.

University of British Columbia, Vancouver, BC, Canada.

 Diabetes 2009;58:641–51.

Editor’s note: The observation that treatment with glucagon-like peptide-1 and dipeptidyl peptidase-IV (DPP-IV) inhibition in rats results in the preservation of islet cell mass led the investigators behind this complex and detailed study to look into the potential for DPP-IV inhibition to improve islet cell function and longevity following transplantation. The MK0431 in the article title will be better known to clinicians as sitagliptin. Sitagliptin was added to the feed of diabetic mice at a dose of 4 g per kg of chow. Three groups of mice were studied: the first group received normal feed for 4 weeks before and 4 weeks after islet transplantation; the second group received normal feed before transplantation and sitagliptin-enhanced feed for 4 weeks after; and the third group received the enhanced feed both before and after transplantation.

Please login or register to continue reading this article
Return to top
Login/Register

Post Page On

LATEST ARTICLES

Our most popular articles