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Basic Science – Complications 
and Comorbidities


Silva KC, Rosales MA, Biswas SK et al.

University of Campinas, Campinas, São Paulo, Brazil.

 Diabetes 2009;58:1382–90.

[2] Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor-to-pigment epithelium-derived factor ratio: involvement of a mitochondria-reactive oxygen species pathway.

Zheng Z, Chen H, Ke G et al.

Shanghai Jiaotong University, Shanghai, China.

 Diabetes 2009;58:954–64.

Editor’s note: Studies of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers in human patients with diabetes have shown a reduced risk for renal complications of the disease and a trend towards retinal protection by inhibiting the renin–angiotensin system.

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