Jiang L, Herzog RI, Mason GF et al.
Yale University, New Haven, CT, USA.
Diabetes 2009;58:1266–74.
[2] Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and supportin vitro synaptic transmission during acute hypoglycemia.
Page KA, Williamson A, Yu N et al.
Yale School of Medicine, New Haven, CT, USA.
Diabetes 2009;58:1237–44.
Editor’s note: A definitive description of the neuronal (cerebral metabolic) effects of recurrent hypoglycemia has been elusive; although studies have been undertaken both in humans and animals, findings have varied depending on the techniques used for investigation. In the first of these two articles, the authors report a study in which whole-brain nuclear magnetic resonance spectroscopy was used in rats to measure cerebral metabolic rates at both euglycemia and hypoglycemia in animals either exposed to recurrent prior hypoglycemia or not exposed (controls) [1]. The relative contributions of glucose and/or acetate metabolism to the overall metabolic rate were examined.