Keske MA, Clerk LH, Price WJ et al.
University of Virginia, Charlottesville, VA, USA.
Diabetes Care 2009;32:1672–7.
Editor’s note: It has been suggested that reduced blood flow to various tissues, particularly skeletal muscle, might contribute to impaired glucose disposal and thus insulin resistance in obesity (
J Clin Invest 1990;85:1844–52), and existing data indicate that insulin can increase the blood flow in muscles (
J Biol Chem 2001;276:30392–8,
Circulation 1999;100:820–5). In the present study, eight obese (body mass index [BMI] >30 kg/m
2) and eight lean (BMI <25 kg/m
2) subjects were recruited. Their microvascular responses to a mixed meal were compared by measuring plasma glucose and insulin levels as well as brachial artery blood flow and muscle microvasculature recruitment for up to 2 h after the meal.