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Basic Science – Complications
and Comorbidities

Keske MA, Clerk LH, Price WJ et al.

University of Virginia, Charlottesville, VA, USA.

 Diabetes Care 2009;32:1672–7.

Editor’s note: It has been suggested that reduced blood flow to various tissues, particularly skeletal muscle, might contribute to impaired glucose disposal and thus insulin resistance in obesity (J Clin Invest 1990;85:1844–52), and existing data indicate that insulin can increase the blood flow in muscles (J Biol Chem 2001;276:30392–8, Circulation 1999;100:820–5). In the present study, eight obese (body mass index [BMI] >30 kg/m2) and eight lean (BMI <25 kg/m2) subjects were recruited. Their microvascular responses to a mixed meal were compared by measuring plasma glucose and insulin levels as well as brachial artery blood flow and muscle microvasculature recruitment for up to 2 h after the meal.

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