Mainie I, Tutuian R, Castell DO.
Medical University South Carolina, Charleston, SC, USA.
J Clin Gastroenterol 2008;42:676–9.
Editor’s note: Treatment with proton pump inhibitors (PPIs) is usually effective for relieving the symptoms of gastroesophageal reflux disease (GERD). However, in many patients this is unsuccessful. The authors of this retrospective study, conducted at the Medical University of South Carolina (Charleston, SC, USA) investigated whether the addition of a histamine 2 receptor antagonist (H2RA) would improve control of acid secretion.