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Olynyk JK, Trinder D, Ramm GA et al.

Fremantle Hospital, Fremantle, WA, Australia.

 Hepatology 2008;48:991–1001.

Editor’s note: Hereditary hemochromatosis is a topic that has had a wealth of new data published since 1996, when the discovery of the HFE gene was made (Nat Genet 1996;13:399–408). In this short review, the authors clearly summarize the content of a recent monothematic congress on the disease. Principally, they comment on the discovery of the iron regulatory hormone, hepicidin (Blood Cells Mol Dis 2002;29:327–35), the low penetrance of the HFE gene, and the fact that gene modifiers still need to be discovered to explain this. Anyone needing a refresher course or updating on genetic hemochromatosis can absorb this well-referenced review in 30 mins.

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