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Autonomous University, Barcelona, Spain.
Aliment Pharmacol Ther 2009;29:397–408.
Editor’s note: The current article details an interesting study in which 59 patients with cirrhosis who had variceal bleeding were randomized to receive either ligation and
β-blockers (nadolol; group 1) or nadolol and isosorbide mononitrate (group 2). Group 2 were monitored by hepatic venous pressure gradient (HVPG) measurement, and if a non-hemodynamic response was found, isosorbide mononitrate was substituted with prazosin.