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GH Deficiency: Genetics

Räz B, Janner M, Petkovic V et al.

University of Bern, Bern, Switzerland.

 J Clin Endocrinol Metab 2008;93:974–80.

Editor’s note: The primary aim in treating growth hormone (GH)-deficient children is improving adult height, which will depend on the frequency, dosage, and duration of recombinant human GH (rhGH) therapy. In addition to these factors, an individual’s response to treatment may also be determined by genetic and epigenetic factors. A common polymorphism in the GH receptor gene (GHR), resulting in deletion of exon 3, has been shown to be associated with variation in the response to GH therapy.

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