Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma.
Tan MH, Wong CF, Tan HL et al.
Epithelial renal cell carcinoma (RCC) is the most common tumor of the adult kidney. RCC can be classified based on histology as clear-cell, papillary, chromophobe, or collecting duct carcinoma. Chromophobe carcinoma and renal oncocytoma (the most common benign renal tumor) represent approximately 9–16% of renal tumors. Patients with chromophobe RCC have a better prognosis than patients with clear-cell RCC. Although chromophobe RCC and renal oncocytoma are considered to be distinct tumors, they share morphological and genetic similarities because of a common underlying biology; therefore, diagnosis can be challenging (Am J Surg Pathol 1998;22:419–24, J Mol Diagn 2005;7:206–18).