Temsirolimus in VEGF-refractory metastatic renal cell carcinoma.
MacKenzie MJ, Rini BI, Elson P et al.
Temsirolimus is an ester analogue of rapamycin that binds to and inhibits mammalian target of rapamycin (mTOR), a serine/threonine kinase that plays a role in the phosphoinositide 3-kinase (PI3K)/AKT pathway that is upregulated in some tumors.