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Quality of Life in Long-Term Survivors from Hodgkin Disease

Henning Flechtner, MD, Jana Marková, MD, Peter Borchmann, MD, 
and Andreas Engert,

Since quality of life (QL) includes physical, psychological and social functioning, and incorporates positive as well as negative aspects, it may be considered a representation of the physical, psychological, and social health of patients after treatment for cancer. Recently, patient-reported outcome (PRO) has become the surrogate for any health-status measurement that comes directly from the patient. According to the US Food and Drug Administration (FDA), PRO measures include “such extremely complex concepts as QL, which is widely understood to be a multi-domain concept with physical, psychological, and social components” [1]. The concern about the late effects of the disease and treatment (including QL) for survivors of cancer provides the impetus to more formally study these issues. Patients with Hodgkin lymphoma now enjoy increased survival due to improvements in treatment; a large number of patients are young and will have many potentially productive years of life after completion of treatment [2]. Clinical trials that do not demonstrate differences in survival or event-free survival may allow recommendations for less toxic treatments based on QL measurements, which might result in increased productivity at work and improved functioning outside of work [3].

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