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Positron Emission Tomography in Hematological Malignancies with an Emphasis on Response Evaluation: Advances, Recent Insights, and Future Perspectives

Lieselot Brepoels, MD, PhD, and Daan Dierickx, MD

There are many types of lymphoma that differ with regard to initial presentation, histopathology, clinical behavior, response to therapy, and prognosis. Several classification systems have been introduced over time and the World Health Organization (WHO) classification is now accepted as the standard such system for hematological malignancies [1]. The WHO classification stratifies lymphoid neoplasms primarily into the categories of Hodgkin lymphoma (HL) and non-Hodgkin lymphomas (NHL). Within the category of NHL, there are a large number of distinct diseases that are broadly categorized in clinical practice as indolent (low-grade) and aggressive (high-grade) subtypes. However, this distinction is not absolute and, over time, more discernible entities have been recognized and continue to be identified.

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