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New Therapies for Diffuse Large B Cell Lymphoma

Zahid Bashir1,2 and Andrew John Davies3


Diffuse large B cell lymphoma (DLBCL) is a heterogeneous disease with specific subtypes and morphological variants [1]. No single genetic abnormality is diagnostic of DLBCL; however, gene-expression profiling identifies germinal center B cell-like (GCB) and activated B cell-like (ABC) as two distinct subtypes, providing important diagnostic and prognostic information (

  • Figure1
). Patients identified as having the ABC subtype have a 5-year overall survival (OS) rate of 30%, compared with an almost 60% 5-year OS rate in the GCB subgroup [2,3].

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