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Therapeutic Targeting of the Myeloma Stem Cell

Carolina Vicente-Dueñas and Isidro Sánchez-García

Multiple myeloma (MM) is characterized by the abnormal expansion of neoplastic plasma cells, and the nature of its cell-of-origin is still controversial. MM remains an incurable disease for the vast majority of patients. The existence of MM stem cells (MMSCs) is considered to be one of the major causes of MM drug resistance, leading to disease relapse. This emphasizes the importance and urgency of developing approaches to target MMSCs. However, the MMSC phenotype remains controversial and very little is known about its molecular characteristics, which makes it difficult to target the MMSC therapeutically.

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