Acute myeloid leukemia ontogeny is defined by distinct somatic mutations.
Lindsley RC, Mar BG, Mazzola E et al.
Dana–Farber Cancer Institute, Boston, MA, USA.
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Blood 2014 Dec 30; Epub ahead of print.
Acute myeloid leukemia (AML) can be classified, on the basis of clinical ontogeny, as secondary AML (s-AML) that occurs upon transformation of a preceding myelodysplastic syndrome (MDS) or myeloproliferative neoplasm, therapy-related AML (t-AML) that develops as a complication of leukemogenic treatments, or de novo AML that arises in the absence of demonstrable treatment exposure or preceding disease.