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Chemotherapy and Radiotherapy

Le Péchoux C. Laplanch A., Faivre-Finn C et al.

Institut Gustave-Roussy, Villejuif, France.

 Annals of Oncology 2011;22:1154–63.

Editor’s note: This study is a secondary analysis of a Phase III trial of prophylactic cranial irradiation in limited-stage SCLC that evaluated 25 Gy versus 36 Gy dosing (Lancet Oncol 2009;10:467–74). That study found no significant difference in the incidence of brain metastases between the two different dosing levels, but surprisingly found a significant increase in mortality in the higher dose arm.

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