WASH is required for lysosomal recycling and efficient autophagic and phagocytic digestion.
King JS, Gueho A, Hagedorn M et al.
Beatson Institute for Cancer Research, Glasgow, UK.
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Mol Biol Cell 2013;24:2714–26.
Gregory Pastores’s review: Disruption of autophagy has been implicated in several lysosomal storage diseases (LSDs). For instance, in Niemann–Pick disease type C, a neurodenegerative LSD, autophagymediated lysosomal cholesterol inhibits proteolytic activity (Hum Mol Genet 2012;21:4876–87).