IFN-beta 1a inhibits the secretion of Th17-polarizing cytokines in human dendritic cells via TLR7 up-regulation.
Zhang X, Jin J, Tang Y et al.
Interferon beta 1a (IFN-b1a) is effective in reducing disease activity in multiple sclerosis (MS), but some of its mechanisms of action are unclear. It has been recently found that the innate immune response against viral pathogens plays a role in the pathogenesis of the autoimmune response in MS.