Magnetization transfer ratio abnormalities reflect clinically relevant grey matter damage in multiple sclerosis.
Fisniku LK, Altmann DR, Cercignani M et al.
Editor’s note: The search for sensitive magnetic resonance imaging (MRI) measures of disease activity and progression in multiple sclerosis (MS) continues. It has long been established that traditional MRI techniques used to assess white matter lesion load do not correlate well with disease progression. There has been increasing interest in the role of gray matter atrophy and gray matter lesions as a more accurate predictor and marker of progression in patients with MS.