Clinically isolated syndrome suggestive of multiple sclerosis: voxelwise regional investigation of white and gray matter.
Raz E, Cercignani M, Sbardella E et al.
Editor’s note: Using a magnetic resonance (MR)-based approach, Raz and colleagues aimed to describe the regional changes occurring in white and gray matter structures in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS). Specifically, voxel-based morphometry (VBM) of MR imaging data was used to determine regions of reduced gray matter volume in patients, and voxel-based analysis of diffusion tensor imaging using tract-based spatial statistics (TBSS) was used to map regions of reduced fractional anisotropy (FA), which is indicative of reduced white matter fiber coherence.