Tear analysis in clinically isolated syndrome as new multiple sclerosis criterion.
Calais G, Forzy Crinquette C et al.
Editor’s note: The detection of oligoclonal bands, and in particular oligoclonal immunoglobulin G (IgG), in the cerebrospinal fluid (CSF) has been used as a diagnostic tool in multiple sclerosis (MS) for many years. The detection of oligoclonal IgG in the CSF has consistently been one of the most reliable CSF markers for MS. In addition, the detection of oligoclonal IgG in patients with clinically isolated syndrome is of clinical interest because studies have suggested that their presence, even in the context of a normal finding on brain magnetic resonance imaging, confers an increased risk of conversion to clinically definite MS (Brain 1990;113:1269–89, Neurology 2008;70:1079–83).