MRI only conversion to multiple sclerosis following a clinically isolated syndrome.
Chard DT, Dalton CM, Swanton J et al.
UCL Institute of Neurology, University College London, London, UK.
Editor’s note: Long-term follow-up studies have demonstrated that up to 80% of patients with clinically isolated syndrome (CIS) who present with an abnormal magnetic resonance imaging (MRI) scan suffer subsequent clinical relapses leading to diagnosis of clinically definite multiple sclerosis (CDMS; Brain 2008;131:808– 17). The present study by Chard et al. investigated the occurrence of radiological conversion to MS, defined as new lesions (disseminated in time and space) seen on subsequent MRI without concurrent manifestation of a second relapse suggesting clinical conversion to MS.