Reorganization in cognitive networks with progression of multiple sclerosis: insights from fMRI.
Loitfelder M, Fazekas F, Petrovic K et al.
Medical University of Graz, Graz, Austria.
Editor’s note: Multiple sclerosis (MS) is – by definition – a multifocal disease that affects many parts of the central nervous system. It remains incompletely understood how the brain responds to lesion development and how it compensates for such damage to maintain function. Functional magnetic resonance imaging (fMRI) studies have repeatedly demonstrated that with increasing inflammatory lesion development, brain regions that are usually inactive during a given task become recruited