Kallio SP, Jakkula E, Purcell S et al.
Finnish Institute for Molecular Medicine, Helsinki, Finland.
Hum Mol Genet 2009;18:1670–83.
Editor’s note: The first genome-wide association study in multiple sclerosis (MS) has recently revealed new loci associated with an increased risk of developing the disease; however, these new loci explain only 0.2% of the variance in the risk of MS development (
N Engl J Med 2007;357:851–62). The authors of this investigation therefore aimed to identify rare but important alleles that have a strong effect on disease susceptibility and give rise to a familial concentration of MS cases.