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Genetics

Ban M, Goris A, Lorentzen AR et al.

Addenbrooke’s, Hospital, University of Cambridge, Cambridge, UK.

 Eur J Hum Genet 2009;17:1309–13.

Editor’s note: The genetics of multiple sclerosis (MS) are not fully understood. It is believed that the development of MS represents a complex interaction between environmental and genetic factors (Lancet 2008;372:1502–17). Attempts to identify candidate genes that impose susceptibility for MS using linkage disequilibrium and segregation analyses have confirmed this complexity, and findings suggest that there are many genes that exert a small influence on susceptibility rather than a few genes with a greater influence (Am J Hum Genet 2005;77:454–67, Am J Med Genet A 2005;135:53–8).

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