Ban M, Goris A, Lorentzen AR et al.
Addenbrooke’s, Hospital, University of Cambridge, Cambridge, UK.
Eur J Hum Genet 2009;17:1309–13.
Editor’s note: The genetics of multiple sclerosis (MS) are not fully understood. It is believed that the development of MS represents a complex interaction between environmental and genetic factors (
Lancet 2008;372:1502–17). Attempts to identify candidate genes that impose susceptibility for MS using linkage disequilibrium and segregation analyses have confirmed this complexity, and findings suggest that there are many genes that exert a small influence on susceptibility rather than a few genes with a greater influence (
Am J Hum Genet 2005;77:454–67,
Am J Med Genet A 2005;135:53–8).