Alonso A, Clark CJ.
University of Minnesota, Minneapolis, MN, USA.
J Neurol Sci 2009;286:73–5.
[2] Estrogen treatment in multiple sclerosis.
Gold SM, Voskuhl RR.
Geffen School of Medicine, University of California Los Angeles, LA, USA.
J Neurol Sci 2009;286:99–103.
Editor’s note: Multiple sclerosis (MS) has consistently been shown to affect women more frequently than men (approximately 2:1) in numerous epidemiological studies. This has led some commentators to propose a role for female sex hormones in the development of the condition. Further support for this theory is derived from the reduction of MS relapses during pregnancy, when sex hormone levels change profoundly, and the potential exacerbation in relapses in the
post partum period (
N Engl J Med 1998;339:285–291).