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Pathogenesis

Soulika AM, Lee E, McCauley E et al.

University of California Davis School of Medicine, Sacramento, CA, USA.

 J Neurosci 2009;29:14965–79.

Editor’s note: Persistent activation of central nervous system innate immunity is thought to play a prominent role in the pathogenesis of axonal loss in multiple sclerosis (MS). The authors of the present study investigated axonal loss in the spinal cord of mice that had been immunized with a myelin oligodendrocyte glycoprotein peptide to induce experimental autoimmune encephalomyelitis (EAE). EAE is an animal model of MS, and is used to assess the efficacy of interventions intended to prevent progressive axonal loss and neurological disability.

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