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Neuromyelitis Optica

Olfactory dysfunction in neuromyelitis optica spectrum disorders.

Zhang LJ, Zhao N, Fu Y et al.

Tianjin Medical University General Hospital, Tianjin, People’s Republic of China.

 J Neurol 2015;262:1890–8.

Clemens Warnke’s review: Neuromyelitis optica spectrum disorders (NMOSDs) are a group of central nervous inflammatory diseases with clinical and paraclinical features that are distinct from multiple sclerosis (MS). Unlike in MS, autoantigens have been identified in this group of diseases that are of potential pathogenic relevance. Antibodies directed against the water channel aquaporin-4 (AQP-4) characterize the disease as an antibody-mediated astrocytopathy.

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