Wang X, Su B, Zheng L et al.
Case Western Reserve University, Cleveland, OH, USA.
J Neurochem 2009;109(Suppl 1):153–9.
Editor’s note: There is increasing interest in the possibility that the robustly documented mitochondrial abnormalities in Alzheimer’s disease play a key (not to say “seminal”) role in the damage to neurons that leads to the clinical manifestations of this disorder. That hypothesis agrees with the massive evidence that brain cells in general and neurons in particular are reliant upon on oxidative metabolism for their function. This review, written in part by two of the champions of the importance of mitochondrial abnormalities in Alzheimer’s disease, summarizes the current evidence.