Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis.
Vojinovic J, Damjanov N, D’Urzo C et al.
Histone deacetylase (HDAC) inhibitors promote binding of transcription factors to nuclear DNA and exhibit anti-inflammatory properties. This small Phase II study evaluated the safety and efficacy of the HDAC inhibitor, givinostat, as a treatment for systemic-onset juvenile idiopathic arthritis (JIA).