Central nervous system involvement in Sjögren’s syndrome: unusual, but not unremarkable – clinical, serological characteristics and outcomes in a large cohort of Italian patients
Massara A, Bonazza S, Castellino G et al.
Primary Sjogren’s syndrome (pSS) is a rare, chronic autoimmune disorder characterized by chronic lymphatic and plasmacellular infiltration of exocrine glands, and extraglandular features involving either peripheral or central nervous system (CNS) involvement. Among pSS patients, the estimated prevalence of peripheral nervous system involvement may be as high as 20%, and the frequency of CNS involvement (which is less clear) may range from 0.3% to 48%. In this study, the authors assessed the clinical patterns and outcomes of CNS involvement in a large cohort of Italian pSS patients.