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Editor’s note: The present authors report the findings of a pilot study in which they sought to analyze the role of standard brain magnetic resonance imaging (MRI), neuropsychological testing, and technecium-99m-ethyl cysteinate dimer (
99mTc-ECD) single-photon emission computed tomography (SPECT) in the assessment of subclinical central nervous system (CNS) involvement in patients with primary Sjögren’s syndrome. The true incidence and type of CNS involvement in patients with primary Sjögren’s syndrome is uncertain and depends on the characteristics of the studied patients and the diagnostic tools used (e.g. imaging techniques).