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1 ratings / 4 average

Pediatric Rheumatology

Vojinovic J, Damjanov N, D’Urzo C et al.

University Clinic Center, Nis, Serbia.

 Arthritis Rheum 2011;63:1452–8.

Editor’s note: Histone deacetylase (HDAC) inhibitors promote binding of transcription factors to nuclear DNA and exhibit anti-inflammatory properties. This small Phase II study evaluated the safety and efficacy of the HDAC inhibitor, givinostat, as a treatment for systemic-onset juvenile idiopathic arthritis (JIA).

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