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Volume 12 Issue 2

Paper of the Month

Butyrate attenuates lipopolysaccharide-induced inflammation in intestinal cells and Crohn’s mucosa through modulation of antioxidant defense machinery

Russo I, Luciani A, De Cicco P et al.
PLoS One 2012;7:e32841. There are multiple lines of evidence to support diverse biological roles for the short-chain fatty acids (SCFAs), in particular butyrate, in the maintenance of mucosal homeostasis. These roles range from energy provision to epigenetic modification of mucosal gene expression. This article describes a further potential role for butyrate in maintaining mucosal integrity in Crohn’s disease.
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Ferric carboxymaltose for iron deficiency anemia in IBD
Dr Rayko Estatiev (Medical University of Vienna, Vienna, Austria) discusses the FERGIcor trial of ferric carboxymaltose for iron deficiency anemia in IBD

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