Formation of antinuclear and double-strand DNA antibodies and frequency of lupus-like syndrome in anti-TNF-alpha antibody-treated patients with inflammatory bowel disease
Beigel F, Schnitzler F, Paul Laubender R et al.
The development of autoantibodies and a lupus-like syndrome (LLS) has been documented in IBD patients treated with anti-tumor necrosis factor (anti-TNF) agents; however, the clinical relevance of autoantibody formation is somewhat unclear. These authors assessed 180 IBD patients treated with infliximab, adalimumab, or both, for the presence of antinuclear antibodies and dsDNA antibodies. They also attempted to identify predictive factors for autoantibody formation and development of LLS.