Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis
Ramasamy S, Nguyen DD, Eston MA et al.
Intestinal alkaline phosphatase (IAP) is a smallintestinal brush border enzyme that functions as a gut mucosal defense factor. In this study, Ramasamy and colleagues demonstrated that orally administered calf IAP is protective in two chronic colitis models, one in which colitis was induced by dextran sodium sulfate and another in which radiation was applied to Wiskott–Aldrich Sydrome Protein-deficient mice.