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Di Sabatino A, Corazza GR. Lancet 2009;373:1480–93.

Di Sabatino and Corazza present an overview of the clinical and diagnostic features of celiac disease in this article. They also provide an up-to-date analysis of the disease pathogenesis and treatment options.

In this review, the authors present a detailed update on celiac disease. This disease is a life-long disorder of the gastrointestinal tract in which there is enhanced small intestinal permeability in genetically susceptible individuals. Celiac disease occurs in both adults and children at rates approaching 1% in Western populations; however, it is thought to be rare in central Africa and East Asia. The disease results from the interactions between gluten and immune, genetic, and environmental factors.

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- Pain Management in IBD
  
  Madhusudan Grover, MD, and Douglas A Drossman, MD
  
  Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN; and UNC Center for Functional GI and Motility Disorders, University of North Carolina, Chapel Hill, NC, USA
  
  Patients with IBD commonly suffer from abdominal pain. While the pain may originate from worsening inflammation and/or its complications, chronic pain in IBD can have multiple influences. In particular, chronic pain is frequently driven by dysregulation of neurophysiological processes at spinal and supraspinal levels, and thus can be influenced by psychosocial factors that upregulate central pain control systems. Therefore, a comprehensive understanding of IBD pain in terms of peripherally (gut) and centrally (brain and spinal cord) acting factors is required. This article details the pathophysiology of chronic pain in IBD and treatment strategies.
- Management of the Extraintestinal Manifestations of IBD
  
  Horace Williams, BSc, MB, MRCP, and Tim Orchard, MA, MD, FRCP
  
  St Mary’s Hospital, Imperial College London NHS Trust, London, UK
  
  IBD is complicated by inflammation at sites distant from the bowel in a large number of patients. In some cases, these extraintestinal events are transient and settle with treatment of the underlying gut disease; however, in a proportion, the extraintestinal features can be severe and persistent, causing as much morbidity as the underlying disease and sometimes even more. This article reviews the common extraintestinal manifestations seen in IBD and the treatments currently available to minimize their impact.
Clinical Reviews
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- Digestive Disease Week 2009: Key Updates in IBD Basic Science
  
  Rekha R Garg, PhD, Joseph R Mercado, and Theresa T Pizarro, PhD
  
  Chicago, IL, USA, 30 May–4 June, 2009
  Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA
  
  Common themes in the IBD investigations presented during Digestive Disease Week (DDW) 2009 included mechanism(s) of epithelial and immune regulation, the role of novel inflammatory/ immune mediators, and the contribution of non-immune cells to the pathogenesis of IBD. This report summarizes the highlights of the IBD basic science presentations, with particular emphasis on novel, unpublished work.

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May 24, 2012

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Pain Management in IBD

Madhusudan Grover, MD, and Douglas A Drossman, MD

Management of the Extraintestinal Manifestations of IBD

Horace Williams, BSc, MB, MRCP, and Tim Orchard, MA, MD, FRCP

Clinical Reviews

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Digestive Disease Week 2009: Key Updates in IBD Basic Science

Rekha R Garg, PhD, Joseph R Mercado, and Theresa T Pizarro, PhD

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Madhusudan Grover, MD, and Douglas A Drossman, MD

Horace Williams, BSc, MB, MRCP, and Tim Orchard, MA, MD, FRCP

Clinical Reviews

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Rekha R Garg, PhD, Joseph R Mercado, and Theresa T Pizarro, PhD

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May 24, 2012

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