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PATHOGENESIS

Corazziari ES. J Pediatr Gastroenterol Nutr 2009;48(Suppl 2):S54–5.

The present author reviews the role of colonic mucus in normal and inflamed mucosa. The protective barrier function of the mucus layer is described, along with the potential mechanisms of defective barrier function that may be present in IBD.

 

Involvement of the intestinal barrier and pathogenic microorganisms in the etiology of IBD has been suspected since the first descriptions of the diseases; however, this has been contradicted by the relative lack of success in controlling the disease with antibiotic treatment. The present short article examined the role of the colonic mucus in normal and inflamed mucosa.

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