Please note that only limited free access to this journal is available in your country or territory.

To access the full content of this article you must purchase it (US$9.49). After payment of this one-off fee, you will gain unrestricted online access to the article and a PDF version sent to your email.

As part of our special introductory offer, after purchasing this article you will have unrestricted access to all the articles in this issue for free!

Registered users can purchase/access the article by logging in below. To register for free click here

Registered users login here:

  • Email Address:
     
  • Password:
     
  •  
If you have forgotten your password click here
0 rating

THERAPEUTICS RESEARCH

Patel H, Barr A, Jeejeebhoy KN et al. Can J Gastroenterol 2009;23:170–6.

There are reports of interstitial nephritis in IBD patients treated with 5-aminosalicylates (5-ASA). The aim of this retrospective study was to investigate whether the long-term use of 5-ASA had detrimental effects on renal function in patients with IBD.

 

5-Aminosalicylic acid (5-ASA) has been linked to a hypersensitivity-induced interstitial nephritis. However, it is unclear if a definite relationship exists between the chronic use of 5-ASA and impaired renal function. This retrospective analysis of 171 consecutive patients with Crohn’s disease and ulcerative colitis (UC) examined serum creatinine levels and body weight pre- and post-5-ASA therapy. The mean age at the start of 5-ASA therapy was 36.2±14.7 years. Fifty-four percent of subjects were female and 73.7% had Crohn’s disease. It is unclear why only 82 of 171 subjects underwent an in-depth analysis. The mean dose of 5-ASA was 3.65±0.85 mg/day with a cumulative dose of 11±7.7 kg over an average of 8.4±5.9 years.

Please login or register to continue reading this article
Return to top
Login/Register

Post Page On

LATEST ARTICLES

Our most popular articles